In the Vue.js framework, handling real-time form validation is crucial to create a smooth and seamless user experience. To address this, you should employ reactive data properties with computed properties for validating form inputs. Here's an example of how you can achieve this:

<template>
  <div class="form">
    <h1>Vue Form Validation</h1>
    <input type="text" v-model="username" @blur="$v.username.$touch()" placeholder="Username*"/>
    <p>{{ usernameErrors[0] }}</p>

    <input type="email" v-model="email" @blur="$v.email.$touch()" placeholder="Email*"/>
    <p>{{ emailErrors[0] }}</p>

    <textarea v-model="message" @blur="$v.message.$touch()" placeholder="Message*"></textarea>
    <p>{{ messageErrors[0] }}</p>

    <button :disabled="$v.$invalid">Submit</button>
  </div>
</template>

<script>
import { required, email } from 'vee-validate/dist/rules';
import { validationMixin } from 'vuex-validator';

export default {
  mixins: [validationMixin],

  data() {
    return {
      username: '',
      email: '',
      message: ''
    };
  },

  computed: {
    ...mapState({
      usernameErrors: state => state.validation.username,
      emailErrors: state => state.validation.email,
      messageErrors: state => state.validation.message
    }),

    $v: mapGetters(['validation']),

    isValid() {
      return this.$v.$invalid;
    }
  },

  validations: {
    username: { required },
    email: { email, required },
    message: { required }
  }
};
</script>

In the above code snippet:

• We import required and email from vee-validate/dist/rules to define our validation rules.
• The validationMixin is imported from vuex-validator, which allows us to integrate Vue Validate into our Vuex store.
• In the data properties, we initialize our form inputs with empty strings.
• We create computed properties to fetch any error messages related to each input field using the mapState function.
• The $v property represents the root validation object for all fields in the form.
• The isValid computed property checks if there are any errors by evaluating whether all fields have validations and are not touched yet ($invalid).

By following these steps, you can real-time validate your Vue.js forms and provide feedback to the user immediately upon submission or when they blur away from an input field.